ea0081rc6.6 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022
Occhi Gianluca
, Bertazza Loris
, Barollo Susi
, Galletta Eva
, Mondin Alberto
, Zovato Stefania
, Iacobone Maurizio
, Zilio Eleonora
, Avallone Serena
, Lefkimmiatis Konstantions
, Di Benedetto Giulietta
, Mian Caterina
, Scaroni Carla
, Regazzo Daniela
The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a 7-transmembrane class B G-protein coupled receptor that mediates the incretin response after nutrient stimulation. Although mostly involved in metabolic disorders, in the last years an improper activation of the GIP/GIPR axis has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. In Medullary Thyroid Cancer (MTC), a neuroendocrine tumor of the parafollicular C...